Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649218 | 0.97 | TBXAS1 (0.42) | PDE3BPDE3ACYP11B1CYP11B2TBXAS1 | |
| SCHEMBL10648512 | 0.95 | TBXAS1 (0.44) | PDE3BPDE3ACYP11B1CYP11B2TBXAS1 | |
| SCHEMBL11115116 | 0.93 | PDE3B (0.44) | PDE3BPDE3ACYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10645457 | 0.85 | CYP11B1 (0.56) | PDE3BPDE3ACYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10646693 | 0.77 | HRH3 (0.54) | MAPT | |
| SCHEMBL10648178 | 0.74 | PDE3B (0.44) | PDE3BPDE3ACYP11B1CYP11B2CYP19A1 | |
| SCHEMBL10646129 | 0.74 | HRH3 (0.53) | MAPT | |
| SCHEMBL7280275 | 0.73 | PDE3B (0.59) | PDE3BPDE3ACYP11B1CYP19A1TBXAS1 | |
| SCHEMBL10648317 | 0.73 | CYP1A2 (0.39) | PDE3BPDE3ACYP11B1CYP11B2MAPT | |
| SCHEMBL10650982 | 0.73 | HRH3 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |