Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 14/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.37 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11115116 | 0.88 | PDE3B (0.44) | CYP11B1CYP11B2PDE3BPDE3ATBXAS1 | |
| SCHEMBL10651613 | 0.85 | PDE3B (0.43) | CYP11B1CYP11B2PDE3BPDE3ATBXAS1 | |
| SCHEMBL10648317 | 0.85 | CYP1A2 (0.39) | CYP11B1CYP11B2PDE3BPDE3ACYP1A2 | |
| SCHEMBL10649218 | 0.84 | TBXAS1 (0.42) | CYP11B1CYP11B2PDE3BPDE3ATBXAS1 | |
| SCHEMBL10650151 | 0.84 | CYP1A2 (0.41) | CYP11B1CYP11B2PDE3BPDE3ACYP1A2 | |
| SCHEMBL10648512 | 0.83 | TBXAS1 (0.44) | CYP11B1CYP11B2PDE3BPDE3ATBXAS1 | |
| SCHEMBL10648091 | 0.79 | PDE3B (0.43) | CYP11B1CYP11B2PDE3BPDE3ATBXAS1 | |
| SCHEMBL10647923 | 0.77 | CYP1A2 (0.38) | CYP11B1CYP11B2PDE3BPDE3ACYP1A2 | |
| SCHEMBL7280421 | 0.76 | PDE3B (0.61) | CYP11B1CYP11B2PDE3BPDE3ACYP19A1 | |
| SCHEMBL13907297 | 0.75 | CYP11B1 (0.68) | CYP11B1CYP11B2TBXAS1CYP19A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |