Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647923 | 0.79 | CYP1A2 (0.38) | HTTGRK6HDAC1HDAC6KMT2A | |
| SCHEMBL10648091 | 0.79 | PDE3B (0.43) | MAPTCYP1A2POLBPDE3APDE3B | |
| SCHEMBL10648115 | 0.77 | LMNA (0.39) | KMT2AMEN1MAPTPOLBPKM | |
| SCHEMBL27568498 | 0.68 | CYP1A2 (0.43) | KMT2AMEN1TSHRCYP1A2POLB | |
| SCHEMBL10648447 | 0.67 | CYP1A2 (0.41) | KMT2AMEN1CYP1A2POLBPKM | |
| SCHEMBL10650257 | 0.67 | PDE3B (0.62) | MAPTCYP1A2PDE3APDE3B | |
| SCHEMBL10650151 | 0.65 | CYP1A2 (0.41) | KMT2AMEN1CYP1A2POLBPKM | |
| SCHEMBL13254741 | 0.65 | MAPT (0.53) | HTTHDAC1HDAC6KMT2AMEN1 | |
| SCHEMBL14256403 | 0.63 | HTT (0.68) | HTTGRK6PRKACAPRKACGPRKACB | |
| SCHEMBL8481298 | 0.62 | GPR119 (0.58) | KMT2AMEN1MAPTCYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |