Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10650242 | 0.88 | SMN1; SMN2 (0.41) | SMN1; SMN2PDE4BPDE3BPDE3ALMNA | |
| SCHEMBL10646110 | 0.85 | CYP11B1 (0.53) | SMN1; SMN2PDE4BPDE3BPDE3ALMNA | |
| SCHEMBL10646023 | 0.85 | SMN1; SMN2 (0.40) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL10650433 | 0.82 | HRH3 (0.46) | SMN1; SMN2PDE4BPDE3BPDE3ALMNA | |
| SCHEMBL10650666 | 0.78 | PDE3B (0.49) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL10724269 | 0.77 | PDE3B (0.42) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL10646442 | 0.76 | PDE3B (0.46) | SMN1; SMN2PDE4BPDE3BPDE3ALMNA | |
| SCHEMBL10727098 | 0.75 | PDE3B (0.39) | SMN1; SMN2PDE4BPDE3BPDE3ALMNA | |
| SCHEMBL10730685 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2PDE4BPDE3BPDE3ALMNA | |
| SCHEMBL10648034 | 0.74 | HRH3 (0.50) | SMN1; SMN2PDE3BPDE3ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |