Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648034 | 0.87 | HRH3 (0.50) | HRH3TDP1L3MBTL1SMN1; SMN2GPR119 | |
| SCHEMBL11119254 | 0.85 | HRH3 (0.54) | HRH3SMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL10646470 | 0.84 | HRH3 (0.53) | HRH3SMN1; SMN2GPR119 | |
| SCHEMBL10650307 | 0.83 | HRH3 (0.52) | HRH3SMN1; SMN2GPR119 | |
| SCHEMBL10650242 | 0.83 | SMN1; SMN2 (0.41) | HRH3MAPTSMN1; SMN2PDE3BPDE3A | |
| SCHEMBL10648684 | 0.82 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL10646110 | 0.78 | CYP11B1 (0.53) | SMN1; SMN2PDE3BPDE3ALMNAPDE4A | |
| SCHEMBL10646023 | 0.78 | SMN1; SMN2 (0.40) | ALDH1A1MAPTTDP1SMN1; SMN2GPR119 | |
| SCHEMBL10650666 | 0.76 | PDE3B (0.49) | MAPTL3MBTL1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL10730685 | 0.74 | SMN1; SMN2 (0.38) | MAPTSMN1; SMN2GPR119PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |