Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11119254 | 0.93 | HRH3 (0.54) | HRH3SMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL10646470 | 0.92 | HRH3 (0.53) | HRH3SMN1; SMN2GPR119 | |
| SCHEMBL10650307 | 0.91 | HRH3 (0.52) | HRH3SMN1; SMN2GPR119 | |
| SCHEMBL10650433 | 0.87 | HRH3 (0.46) | HRH3SMN1; SMN2GPR119TDP1L3MBTL1 | |
| SCHEMBL10646442 | 0.79 | PDE3B (0.46) | SMN1; SMN2PDE3BPDE3ACYP1A2CYP3A4 | |
| SCHEMBL10724467 | 0.77 | PDE3B (0.47) | HRH3SMN1; SMN2PDE3BPDE3APDE2A | |
| SCHEMBL10650242 | 0.75 | SMN1; SMN2 (0.41) | HRH3SMN1; SMN2PDE3BPDE3APDE2A | |
| SCHEMBL10648178 | 0.75 | PDE3B (0.44) | PDE3BPDE3ACYP1A2CYP3A4 | |
| SCHEMBL10648684 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2GPR119PDE3BPDE3APDE2A | |
| SCHEMBL10645518 | 0.74 | PDE3B (0.43) | PDE3BPDE3ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |