Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412923 | 0.95 | SLC18A3 (0.47) | DRD2DRD4DRD3MAOBMAOA | |
| SCHEMBL10650789 | 0.93 | DRD2 (0.39) | DRD2DRD4DRD3MAOBMAOA | |
| SCHEMBL10650004 | 0.93 | DRD2 (0.47) | DRD2DRD4DRD3SLC18A3SIGMAR1 | |
| SCHEMBL10648649 | 0.92 | DRD2 (0.43) | DRD2DRD4DRD3MAOBMAOA | |
| SCHEMBL10412992 | 0.88 | SLC18A3 (0.47) | DRD2DRD4DRD3MAOBMAOA | |
| SCHEMBL10648783 | 0.86 | DRD2 (0.49) | DRD2DRD4DRD3AVPR1ASLC18A3 | |
| SCHEMBL10413621 | 0.86 | DRD2 (0.45) | DRD2DRD4DRD3MAOBMAOA | |
| SCHEMBL10648604 | 0.86 | TRPV1 (0.39) | DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10648539 | 0.85 | DRD2 (0.43) | DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10652767 | 0.85 | DRD2 (0.48) | DRD2DRD4DRD3MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |