Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10413001 | 0.95 | MAOB (0.52) | DRD2DRD4DRD3MAOBMAOA | |
| SCHEMBL10648427 | 0.93 | MAOB (0.44) | MAOB | |
| SCHEMBL10647445 | 0.93 | HTR1A (0.52) | — | |
| SCHEMBL10646279 | 0.92 | MAOB (0.45) | DRD2DRD4DRD3MAOBMAOA | |
| SCHEMBL9828847 | 0.88 | HTR1A (0.54) | — | |
| SCHEMBL11351695 | 0.87 | HTR1A (0.60) | SIGMAR1 | |
| SCHEMBL9582259 | 0.85 | KMT2A (0.54) | DRD2DRD4DRD3SIGMAR1MEN1 | |
| SCHEMBL10646937 | 0.85 | HTR1A (0.50) | — | |
| SCHEMBL10648787 | 0.85 | DRD2 (0.47) | DRD2DRD4DRD3MAOBSIGMAR1 | |
| SCHEMBL10414161 | 0.85 | DRD2 (0.47) | DRD2DRD4DRD3MAOBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |