Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10650004 | 0.95 | DRD2 (0.47) | SLC18A3DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10412923 | 0.93 | SLC18A3 (0.47) | SLC18A3DRD2DRD4DRD3MAOA | |
| SCHEMBL10412980 | 0.92 | HTR1D (0.47) | SLC18A3DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10413746 | 0.92 | HTR1A (0.48) | SLC18A3DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10414153 | 0.91 | DRD2 (0.43) | SLC18A3DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10413339 | 0.91 | DRD2 (0.45) | SLC18A3DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10414224 | 0.90 | SIGMAR1 (0.46) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10412977 | 0.89 | SIGMAR1 (0.46) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10412925 | 0.89 | DRD2 (0.41) | SLC18A3DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10648604 | 0.89 | TRPV1 (0.39) | DRD2DRD4DRD3SIGMAR1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |
| EP-0241654-A1 | Hydroxyindole esters | MERCK PATENT GmbH (DE) | 1987-10-21 | — | — | EP | disclosed |