Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648014 | 0.81 | PDE3B (0.41) | PDE3BPDE3AGPR119HRH3ROCK1 | |
| SCHEMBL10651151 | 0.78 | PDE3B (0.37) | PDE3BPDE3AGPR119 | |
| SCHEMBL10645524 | 0.78 | PDE3B (0.61) | PDE3BPDE3AGPR119PIM1HRH3 | |
| SCHEMBL12195521 | 0.67 | SMN1; SMN2 (0.38) | MAOBADORA2AADORA1 | |
| SCHEMBL10649995 | 0.65 | SMN1; SMN2 (0.39) | PDE3BPDE3A | |
| SCHEMBL26672756 | 0.65 | GPR119 (0.59) | PDE3BPDE3AGPR119ROCK1MET | |
| SCHEMBL10646441 | 0.64 | PBRM1 (0.49) | PDE3BPDE3AGPR119 | |
| SCHEMBL10353678 | 0.64 | PDE3B (0.63) | PDE3BPDE3AGPR119HRH3ROCK1 | |
| SCHEMBL31553322 | 0.62 | PIM1 (0.40) | PDE3BPDE3APIM1HRH3 | |
| SCHEMBL31553324 | 0.62 | PIM1 (0.40) | PDE3BPDE3APIM1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |