Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648980 | 0.78 | PDE3B (0.41) | PDE3BPDE3AGPR119 | |
| SCHEMBL10648447 | 0.78 | CYP1A2 (0.41) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL7280416 | 0.74 | PDE3B (0.58) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL31553322 | 0.72 | PIM1 (0.40) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL31553324 | 0.72 | PIM1 (0.40) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL13464837 | 0.69 | KMT2A (0.55) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL10650872 | 0.67 | KMT2A (0.37) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL10646441 | 0.66 | PBRM1 (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL1456606 | 0.65 | CYP1A2 (0.67) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL10645457 | 0.64 | CYP11B1 (0.56) | PDE3BPDE3ACYP1A2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |