Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582013 | 0.89 | DRD3 (0.46) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL10649693 | 0.88 | DRD4 (0.46) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL10648282 | 0.80 | DRD3 (0.46) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL11013556 | 0.80 | SIGMAR1 (0.46) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL10648443 | 0.79 | PROKR1 (0.33) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL10646688 | 0.78 | HRH3 (0.35) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL9582245 | 0.76 | DRD4 (0.47) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL9581681 | 0.73 | SIGMAR1 (0.47) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL9582397 | 0.73 | DRD3 (0.47) | DRD3DRD4SIGMAR1DRD2NFKB1 | |
| SCHEMBL9581321 | 0.72 | PRKAB2 (0.35) | DRD3DRD4SIGMAR1DRD2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |