Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.47 |
| ▸ | DRD3 | P35462 | 9/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PRCP | P42785 | 1/20 | 0.47 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | DRD1 | P21728 | 7/20 | 0.44 |
| ▸ | DRD5 | P21918 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649693 | 0.89 | DRD4 (0.46) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL9582013 | 0.87 | DRD3 (0.46) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL9581735 | 0.82 | SIGMAR1 (0.48) | SIGMAR1 | |
| SCHEMBL9581488 | 0.77 | DRD4 (0.49) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL9581837 | 0.77 | KDM4E (0.54) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL10649037 | 0.76 | DRD3 (0.44) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL7282059 | 0.75 | DRD4 (0.55) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL7279314 | 0.75 | DRD4 (0.55) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL7281777 | 0.75 | DRD4 (0.55) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL10647591 | 0.74 | DRD4 (0.47) | DRD4DRD3DRD2SIGMAR1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |