Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.45 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10671837 | 0.86 | BRD4 (0.46) | ALDH1A1ALDH1A2ALDH2ALDH3A1ALDH1A3 | |
| SCHEMBL10649474 | 0.85 | ALDH1A1 (0.47) | ALDH1A1GAAHTR6SMN1; SMN2DRD2 | |
| SCHEMBL10671525 | 0.83 | SMN1; SMN2 (0.47) | KDM4EALDH1A1LMNASMN1; SMN2FAAH | |
| SCHEMBL10668329 | 0.83 | BRD4 (0.45) | KDM4EALDH1A1GAASMN1; SMN2DRD2 | |
| SCHEMBL10648058 | 0.82 | MC4R (0.59) | ALDH1A1LMNAL3MBTL1POLBAVPR1A | |
| SCHEMBL30810302 | 0.82 | KDM4E (0.72) | KDM4EALDH1A1GAALMNAHTR6 | |
| SCHEMBL6928385 | 0.82 | KDM4E (0.72) | KDM4EALDH1A1GAALMNAHTR6 | |
| SCHEMBL10646620 | 0.81 | SIGMAR1 (0.54) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL10671068 | 0.80 | HRH3 (0.44) | ALDH1A1DRD2DRD3KCNH2FAAH | |
| SCHEMBL10647221 | 0.77 | MAP4K4 (0.39) | KDM4EALDH1A1LMNASMN1; SMN2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261804-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-03-30 | — | — | EP | disclosed |