Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10646470 | 0.99 | HRH3 (0.53) | HRH3SIGMAR1MAOAMAOBHRH1 | |
| SCHEMBL11119254 | 0.95 | HRH3 (0.54) | HRH3SIGMAR1MAOAMAOBGPR119 | |
| SCHEMBL10648034 | 0.91 | HRH3 (0.50) | HRH3GPR119SMN1; SMN2 | |
| SCHEMBL10650433 | 0.83 | HRH3 (0.46) | HRH3GPR119SMN1; SMN2 | |
| SCHEMBL10977421 | 0.81 | PDE3B (0.42) | — | |
| SCHEMBL10924625 | 0.81 | PDE3B (0.42) | — | |
| SCHEMBL10922175 | 0.81 | PDE3B (0.42) | — | |
| SCHEMBL10926514 | 0.81 | PDE3B (0.42) | — | |
| SCHEMBL10926117 | 0.81 | PDE3B (0.42) | — | |
| SCHEMBL10926374 | 0.81 | PDE3B (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |