Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334549 | 0.85 | MAPT (0.57) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3601604 | 0.84 | CYP1A2 (0.58) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10510370 | 0.83 | ALDH1A1 (0.51) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10510363 | 0.83 | ALDH1A1 (0.51) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10652124 | 0.83 | MEN1 (0.44) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10653936 | 0.83 | MAPT (0.49) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3823448 | 0.80 | ALDH1A1 (0.54) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10651304 | 0.80 | ALDH1A1 (0.46) | MAPTLMNAALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL14099278 | 0.79 | ALDH1A1 (0.55) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2436193 | 0.79 | CYP1A2 (0.63) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |