Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PDE2A | O00408 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280962 | 0.84 | PDE3B (1.00) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL7292854 | 0.81 | PDE3B (0.73) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL2798028 | 0.78 | SMN1; SMN2 (1.00) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL7281065 | 0.78 | PDE3B (0.72) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL7277657 | 0.77 | PDE3B (0.70) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL7290985 | 0.76 | PDE3B (0.69) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL7287604 | 0.74 | PDE3B (0.70) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL7280920 | 0.74 | PDE3B (1.00) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL10651088 | 0.73 | PDE3B (1.00) | PDE3BPDE3ASMN1; SMN2PDE2ALMNA | |
| SCHEMBL528245 | 0.73 | MAPK9 (0.54) | SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |