Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | USP10 | Q14694 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10651899 | 0.85 | MAPT (0.52) | MAPTMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL10651245 | 0.84 | ALDH1A1 (0.56) | MAPTALDH1A1PDE7ATDP1ATM | |
| SCHEMBL3487377 | 0.84 | KMT2A (0.55) | MAPTMEN1KMT2AHPGDGAA | |
| SCHEMBL29256260 | 0.82 | HPGD (0.53) | MAPTMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL10648433 | 0.80 | ALDH1A1 (0.47) | MAPTMEN1KMT2AALDH1A1PDE7A | |
| SCHEMBL6558543 | 0.78 | PDE7A (0.54) | MAPTKMT2AALDH1A1PDE7ATDP1 | |
| SCHEMBL2247990 | 0.77 | PDGFRB (0.52) | MAPTKMT2AHPGDGAAALDH1A1 | |
| SCHEMBL10648807 | 0.77 | MAPT (0.48) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL12466651 | 0.76 | MAPT (0.53) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2610870 | 0.75 | MAPT (0.49) | MAPTKMT2AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |