Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | USP10 | Q14694 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558543 | 0.84 | PDE7A (0.54) | ALDH1A1PDE7ATDP1ATMUSP10 | |
| SCHEMBL10652731 | 0.84 | ALDH1A1 (0.55) | ALDH1A1PDE7AUSP7USP47MAPK1 | |
| SCHEMBL10651192 | 0.84 | MAPT (0.49) | ALDH1A1PDE7ATDP1ATMUSP10 | |
| SCHEMBL8941930 | 0.80 | ALDH1A1 (0.50) | ALDH1A1PDE7AHTTMAPT | |
| SCHEMBL10651794 | 0.78 | PDE7A (0.51) | ALDH1A1PDE7AUSP7USP47MAPK1 | |
| SCHEMBL3874156 | 0.76 | PDE7A (0.58) | ALDH1A1PDE7ATDP1ATMUSP10 | |
| SCHEMBL1970520 | 0.76 | ATM (0.46) | ALDH1A1PDE7ATDP1ATMHTT | |
| SCHEMBL1970519 | 0.76 | ATM (0.46) | ALDH1A1PDE7ATDP1ATMHTT | |
| SCHEMBL9850838 | 0.75 | LMNA (0.47) | ALDH1A1PDE7AHTT | |
| SCHEMBL10649323 | 0.75 | PDE7A (0.48) | ALDH1A1PDE7ATDP1ATMUSP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |