Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CTSC | P53634 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144586 | 0.81 | ALOX5 (0.38) | ALOX5CES2CES1KEAP1MAPT | |
| SCHEMBL5229338 | 0.78 | CCR1 (0.45) | CCR1ALOX5PGRCES2CES1 | |
| SCHEMBL28611237 | 0.77 | CTSC (0.42) | CCR1ALDH1A1MEN1KMT2ACTSC | |
| SCHEMBL9521376 | 0.75 | FFAR1 (0.45) | CCR1ALOX5CES2CES1KEAP1 | |
| SCHEMBL9442383 | 0.74 | — | — | |
| SCHEMBL3411347 | 0.73 | CTSC (0.44) | CCR1MAPTALDH1A1RAB9ALMNA | |
| SCHEMBL963358 | 0.73 | ALOX5 (0.39) | CCR1ALOX5PGRCES2CES1 | |
| SCHEMBL7596019 | 0.73 | ALOX5 (0.43) | CCR1ALOX5PGRCES2CES1 | |
| SCHEMBL2880798 | 0.73 | ALOX5 (0.39) | ALOX5CES2CES1KEAP1MAPT | |
| SCHEMBL31331749 | 0.72 | MGAM (0.51) | ALOX5CES1MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0171213-B1 | SPIRO-IMIDAZOLONES FOR TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4680306-A | Sprio-imidazolones for treatment of diabetes complications | PFIZER INC. (US) | 1987-07-14 | — | — | US | disclosed |
| WO-1986000807-A1 | SPIRO-IMIDAZOLONES FOR TREATMENT OF DIABETES COMPLICATIONS | PFIZER INC. (US) | 1986-02-13 | — | — | WO | disclosed |
| EP-0171213-A1 | Spiro-imidazolones for treatment of diabetic complications | PFIZER INC. (US) | 1986-02-12 | — | — | EP | disclosed |