Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648332 | 0.91 | ACHE (0.39) | CYP19A1CYP11B1CYP11B2CYP3A4TBXAS1 | |
| SCHEMBL10649044 | 0.86 | ACHE (0.40) | CYP11B1CYP11B2KDM4EPOLBCYP3A4 | |
| SCHEMBL10650460 | 0.84 | CYP11B1 (0.46) | CYP11B1CYP11B2TSHRMETKDM4E | |
| Hydrochloric Acid SCHEMBL10648181 | 0.83 | CYP11B1 (0.46) | CYP11B1CYP11B2TSHRKDM4EPOLB | |
| SCHEMBL10646247 | 0.83 | CYP3A4 (0.45) | TSHRMETKDM4EPOLBCYP3A4 | |
| SCHEMBL10648854 | 0.77 | CYP11B1 (0.47) | CYP11B1CYP11B2KDM4ECYP3A4 | |
| SCHEMBL10648690 | 0.77 | CYP11B1 (0.46) | CYP11B1CYP11B2KDM4EPOLBCYP3A4 | |
| Hydrochloric Acid SCHEMBL10646340 | 0.77 | CYP11B1 (0.46) | CYP11B1CYP11B2KDM4ECYP3A4 | |
| Hydrochloric Acid SCHEMBL10651008 | 0.76 | CYP11B1 (0.46) | CYP11B1CYP11B2KDM4EPOLBCYP3A4 | |
| SCHEMBL10646403 | 0.75 | CYP3A4 (0.43) | TSHRKDM4EPOLBCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |