Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10651008 | 0.99 | CYP11B1 (0.46) | CYP11B1CYP11B2ACHEALOX15MEN1 | |
| SCHEMBL10648854 | 0.99 | CYP11B1 (0.47) | CYP11B1CYP11B2ACHEALOX15MEN1 | |
| Hydrochloric Acid SCHEMBL10646340 | 0.98 | CYP11B1 (0.46) | CYP11B1CYP11B2ACHEALOX15MEN1 | |
| SCHEMBL10646977 | 0.94 | CYP11B1 (0.45) | CYP11B1CYP11B2ACHEALOX15MEN1 | |
| SCHEMBL10650408 | 0.94 | CYP11B1 (0.45) | CYP11B1CYP11B2ACHEALOX15MEN1 | |
| Hydrochloric Acid SCHEMBL10648154 | 0.93 | CYP11B1 (0.44) | CYP11B1CYP11B2ACHEALOX15MEN1 | |
| SCHEMBL10650460 | 0.92 | CYP11B1 (0.46) | CYP11B1CYP11B2ACHECYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL10648181 | 0.91 | CYP11B1 (0.46) | CYP11B1CYP11B2ACHECYP3A4CYP2D6 | |
| SCHEMBL10648332 | 0.83 | ACHE (0.39) | CYP11B1CYP11B2ACHEALOX15MEN1 | |
| SCHEMBL11115052 | 0.81 | SIGMAR1 (0.41) | ALOX15MEN1CYP3A4GAACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |