Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 13/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | CES1 | P23141 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3687782 | 0.80 | P2RX4 (0.44) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL5367306 | 0.78 | LMNA (0.42) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3691734 | 0.78 | LMNA (0.55) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1248214 | 0.78 | P2RX4 (0.46) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL5803934 | 0.75 | P2RX4 (0.33) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL11619656 | 0.74 | LMNA (0.58) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL5172363 | 0.74 | BCHE (0.46) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL5367522 | 0.73 | P2RX4 (0.37) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL5806375 | 0.72 | LMNA (0.37) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL8672568 | 0.71 | P2RX4 (0.46) | LMNATSHRMAPK1SCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127423-B1 | 1-(4'-BRANCHED ALKYLSULFONYLPHENYL)-6-CHLORO-7,8-DIHYDROXY-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-03 | — | — | EP | disclosed |
| US-4514394-A | Anti-hypertensive use of 1-(4'-branched alkylsulfonylphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1985-04-30 | — | — | US | disclosed |
| EP-0127423-A2 | 1-(4'-Branched alkylsulfonylphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |