Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6838403 | 1.00 | LMNA (0.47) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| Melphalan Flufenamide SCHEMBL24101233 | 0.92 | LMNA (0.53) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| Melphalan Flufenamide SCHEMBL18239898 | 0.92 | LMNA (0.53) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| Melphalan Flufenamide SCHEMBL20208719 | 0.92 | LMNA (0.53) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| Melphalan Flufenamide SCHEMBL29375249 | 0.91 | LMNA (0.52) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| Ambamustine SCHEMBL62822 | 0.90 | LMNA (0.41) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| Ambamustine SCHEMBL1419557 | 0.90 | LMNA (0.40) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| SCHEMBL10657935 | 0.88 | LMNA (0.55) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 | |
| SCHEMBL10972441 | 0.88 | LMNA (0.43) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL25022336 | 0.86 | LMNA (0.43) | LMNASMN1; SMN2CYP3A4ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4743590-A | METHIONINE, 3-(P-FLUOROPHENYL)ALANINE, 3-(M-BIS(2-CHLOROETHYL)AMINOPHENYL)ALANINE | DEBARBIERI AUGUSTO (IT) | 1988-05-10 | — | — | US | disclosed |
| US-4740501-A | ANTITUMOR AGENT | PROTER S.P.A. (IT) | 1988-04-26 | — | — | US | disclosed |
| US-4540683-A | In vitro and in vivo treatment of cancer cells and treatment of viruses with a tripeptide compound | PROTER S.P.A. (IT) | 1985-09-10 | — | — | US | disclosed |