SCHEMBL5533664

SCHEMBL5533664

CCOC(=O)Oc1noc2c1CN(C(C)=O)CC2

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 4/20 0.45
HSP90AA1 P07900 6/20 0.44
SHMT2 P34897 1/20 0.40
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
EP300 Q09472 3/20 0.33
CREBBP Q92793 3/20 0.33
HTR6 P50406 1/20 0.33
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32
KCNH2 Q12809 1/20 0.32
BRD4 O60885 1/20 0.32
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10653028 0.80 CHRM3 (0.60) CHRM3HSP90AA1SHMT2HTR2CEP300
SCHEMBL2582148 0.80 HSP90AA1 (0.64) CHRM3HSP90AA1SHMT2HTR2CLMNA
SCHEMBL10653973 0.79 CHRM3 (0.58) CHRM3HSP90AA1HTR2CLMNAMAPT
SCHEMBL17232774 0.76 SHMT2 (0.54) HSP90AA1SHMT2EP300CREBBPHTR6
SCHEMBL10656780 0.76 HSP90AA1 (0.50) CHRM3HSP90AA1LMNAMAPT
SCHEMBL5533290 0.73 CHRM3 (0.63) CHRM3HTR2AHTR2C
SCHEMBL10656068 0.73 HSP90AA1 (0.52) CHRM3HSP90AA1LMNAMAPT
SCHEMBL10655106 0.72 CHRM3 (0.60) CHRM3HSP90AA1HTR2AHTR2C
SCHEMBL17229748 0.70 SHMT2 (0.42) HSP90AA1SHMT2EP300CREBBPBRD4
SCHEMBL11115776 0.70 CHRM3 (0.60) CHRM3HSP90AA1HTR2CLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP disclosed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO disclosed