Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28464466 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16372005 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNA | |
| SCHEMBL28187319 | 0.71 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL27672566 | 0.69 | ALDH1A1 (0.36) | SMN1; SMN2GSK3AGSK3BALDH1A1MEN1 | |
| SCHEMBL4120181 | 0.68 | SMN1; SMN2 (0.44) | SMN1; SMN2 | |
| SCHEMBL25759298 | 0.68 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6180556 | 0.68 | ALDH1A1 (0.37) | SMN1; SMN2GSK3AGSK3BALDH1A1MEN1 | |
| SCHEMBL22235641 | 0.67 | HRH1 (0.36) | SMN1; SMN2HRH1GSK3AGSK3BALDH1A1 | |
| SCHEMBL9443608 | 0.66 | MAPT (0.32) | HRH1GSK3AGSK3BMEN1KMT2A | |
| SCHEMBL11210177 | 0.66 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0119087-B1 | 2-(2-HYDROXY-4-(SUBSTITUTED) PHENYL) PIPERIDINES | PFIZER INC. (US) | 1988-10-05 | — | — | EP | disclosed |
| US-4529732-A | Analgesics | PFIZER INC. (US) | 1985-07-16 | — | — | US | disclosed |
| EP-0119087-A1 | 2-(2-Hydroxy-4-(substituted) phenyl) piperidines | PFIZER INC. (US) | 1984-09-19 | — | — | EP | disclosed |