Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9352348 | 0.95 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL9352380 | 0.94 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL9351767 | 0.89 | FEN1 (0.54) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL9352330 | 0.85 | FEN1 (0.51) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL9348332 | 0.85 | MAPT (0.45) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL9348282 | 0.84 | FEN1 (0.50) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL9348245 | 0.84 | PKM (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL9348174 | 0.84 | MAPT (0.44) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL10667933 | 0.83 | PKM (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL9348372 | 0.83 | FEN1 (0.49) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |