Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.43 |
| ▸ | PPARD | Q03181 | 9/20 | 0.43 |
| ▸ | PPARA | Q07869 | 8/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10663597 | 0.88 | PPARG (0.45) | PPARGPPARDPPARAFFAR1ALOX5AP | |
| SCHEMBL10662754 | 0.86 | FHIT (0.47) | PPARGPPARDPPARAFFAR1PTGDR2 | |
| Brocrinat SCHEMBL29452050 | 0.86 | PPARG (0.43) | PPARGPPARDPPARAFFAR1ALOX5AP | |
| SCHEMBL4035353 | 0.86 | FFAR4 (0.44) | PPARGPPARDPPARAFFAR1ALOX5AP | |
| Brocrinat SCHEMBL636178 | 0.86 | PPARG (0.43) | PPARGPPARDPPARAFFAR1ALOX5AP | |
| SCHEMBL10734539 | 0.82 | TP53 (0.37) | PPARGPPARDPPARAALOX5APFEN1 | |
| SCHEMBL10737050 | 0.81 | HTR7 (0.34) | PPARGPPARDPPARA | |
| SCHEMBL10655938 | 0.79 | NPC1 (0.43) | MEN1POLBKMT2AKDM4EALDH1A1 | |
| SCHEMBL10732931 | 0.78 | RAB9A (0.45) | MEN1KMT2AALDH1A1HPGDTDP1 | |
| SCHEMBL10661581 | 0.78 | FFAR4 (0.41) | PPARGPPARDPPARAFFAR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | claimed |
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0002666-B1 | 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-17 | — | — | EP | disclosed |