Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2899875 | 0.84 | ATM (0.60) | ATMNPSR1ALDH1A1HPGDMAPT | |
| SCHEMBL4354117 | 0.81 | MEN1 (0.54) | ALDH1A1HPGDCYP2C9MAPTRAB9A | |
| SCHEMBL4352792 | 0.78 | MEN1 (0.58) | ALDH1A1MEN1KMT2AALPL | |
| SCHEMBL2430238 | 0.75 | NPC1 (0.53) | NPSR1ALDH1A1HPGDCYP2C9MAPT | |
| SCHEMBL581143 | 0.72 | NPSR1 (1.00) | ATMNPSR1ALDH1A1HPGDMAPT | |
| SCHEMBL29870198 | 0.72 | NPSR1 (1.00) | ATMNPSR1ALDH1A1HPGDMAPT | |
| SCHEMBL14611730 | 0.72 | HSD17B10 (0.51) | NPSR1ALDH1A1HPGDCYP2C9MAPT | |
| SCHEMBL11169740 | 0.71 | MEN1 (0.65) | ATMNPSR1ALDH1A1HPGDMAPT | |
| SCHEMBL11480060 | 0.71 | NPSR1 (0.63) | ATMNPSR1ALDH1A1HPGDMAPT | |
| SCHEMBL20798351 | 0.70 | XDH (0.55) | ALDH1A1HPGDMAPTGFERNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222326-B2 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | VIB VZW (BE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2222326-B1 | Inhibitors of MALT1-proteolytic activity and uses thereof | VIB VZW (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | MMEL1, CTRL, ZFR | ATM 3701/4885NPSR1 2236/4885ALDH1A1 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.