Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.50 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2677030 | 0.83 | ATM (1.00) | ATMALDH1A1HPGDLMNATSHR | |
| SCHEMBL1064811 | 0.82 | EPHX2 (0.79) | ATMSMN1; SMN2ALDH1A1KMT2AHPGD | |
| SCHEMBL9827968 | 0.82 | ATM (0.90) | ATMSMN1; SMN2ALDH1A1KMT2AHPGD | |
| SCHEMBL5656019 | 0.80 | ATM (0.87) | ATMALDH1A1HPGDLMNATSHR | |
| SCHEMBL6349089 | 0.80 | ATM (0.87) | ATMALDH1A1HPGDLMNATSHR | |
| SCHEMBL9830686 | 0.79 | ATM (0.65) | ATMSMN1; SMN2ALDH1A1KMT2AHPGD | |
| SCHEMBL28992291 | 0.79 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL644993 | 0.79 | EPHX2 (0.62) | SMN1; SMN2ALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL6793462 | 0.79 | PYGL (0.66) | ATMSMN1; SMN2LMNATSHRTRPV1 | |
| SCHEMBL4079697 | 0.78 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476043-B2 | Inhibitors for the soluble epoxide hydrolase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-07-02 | — | — | US | disclosed |
| CN-101084216-B | Inhibitors for the soluble epoxide hydrolase | UNIV CALIFORNIA | 2011-09-14 | — | — | CN | disclosed |
| US-20110021448-A1 | Inhibitors for the Soluble Epoxide Hydrolase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-27 | — | — | US | disclosed |
| US-7662910-B2 | Inhibitors for the soluble epoxide hydrolase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-02-16 | — | — | US | disclosed |
| CN-101084216-A | Inhibitors for the soluble epoxide hydrolase | UNIV CALIFORNIA (US) | 2007-12-05 | — | — | CN | disclosed |
| EP-1814875-A2 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | The Regents of the University of California (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20060270609-A1 | Inhibitors for the soluble epoxide hydrolase | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-11-30 | — | — | US | disclosed |
| WO-2006045119-A2 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270609-A1 | Inhibitors for the soluble epoxide hydrolase | EPHX1, EPHX2, NCEH1 | ATM 4861/4885SMN1; SMN2 2846/4885ALDH1A1 293/4885 |
| US-20110021448-A1 | Inhibitors for the Soluble Epoxide Hydrolase | EPHX1, EPHX2, NCEH1 | ATM 4861/4885SMN1; SMN2 2846/4885ALDH1A1 293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.