Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656600 | 0.92 | ABL1 (0.58) | ABL1MEN1KMT2AATMHSD17B10 | |
| SCHEMBL11059739 | 0.85 | ABL1 (0.49) | ABL1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL25138507 | 0.80 | ABL1 (1.00) | ABL1MAPTSMN1; SMN2 | |
| SCHEMBL25703688 | 0.80 | ABL1 (1.00) | ABL1MAPTSMN1; SMN2 | |
| SCHEMBL11091577 | 0.79 | ABL1 (0.42) | ABL1MEN1KMT2AATMHSD17B10 | |
| SCHEMBL10959459 | 0.73 | L3MBTL1 (0.40) | ABL1MEN1KMT2AATMKDM4E | |
| SCHEMBL972562 | 0.73 | L3MBTL1 (0.43) | ABL1MEN1KMT2AATMKDM4E | |
| SCHEMBL11060224 | 0.71 | ABL1 (0.49) | ABL1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL11059744 | 0.70 | MEN1 (0.66) | ABL1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL974864 | 0.70 | ABCB11 (0.47) | MEN1KMT2AHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022578-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 3-AMINO-PYRAZOLINE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-06-29 | — | — | EP | disclosed |
| US-4556671-A | Pharmaceutical formulations | BURROUGHS WELLCOME CO. (US) | 1985-12-03 | — | — | US | disclosed |
| US-4530994-A | Reduced viscosity | Osaka Suda Co Ltd (JP) | 1985-07-23 | — | — | US | disclosed |
| US-4448973-A | ANTIINFLAMMATORY, ANALGESIC AGENTS; BACTERICIDES, FUNGICIDES | AMERICAN CYANAMID COMPANY (US) | 1984-05-15 | — | — | US | disclosed |
| US-4447442-A | ANTIINFLAMMATORY, ANTIARTHRITIC, ANTIHISTAMINE, ANTIALLERGENS, ANALGESICS, BACTERICIDES, AND FUNGICIDES | AMERICAN CYANAMID COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0070376-A1 | Heterocyclic substituted-amino-pyrazolines | AMERICAN CYANAMID COMPANY (US) | 1983-01-26 | — | — | EP | disclosed |
| US-4348527-A | ANALGESICS, BACTERICIDES, FUNGICIDES | AMERICAN CYANAMID COMPANY (US) | 1982-09-07 | — | — | US | disclosed |
| EP-0022578-A1 | Pharmaceutical compositions containing 3-Amino-pyrazoline derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-01-21 | — | — | EP | disclosed |