Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579030 | 0.85 | MAPK1 (0.50) | HTR1ASLC6A4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL30355131 | 0.84 | HTR3A (0.54) | HTR1ASLC6A4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL4553001 | 0.84 | HTR3A (0.54) | HTR1ASLC6A4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL30480900 | 0.82 | MAPK1 (0.59) | HTR1ASLC6A4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL27771950 | 0.82 | HTR3E (0.56) | HTR1ASLC6A4MAPK1CA12CA9 | |
| SCHEMBL4553923 | 0.82 | MAPK1 (0.59) | HTR1ASLC6A4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL31590550 | 0.80 | ALDH1A1 (0.46) | HTR1ASLC6A4SLC6A2SLC6A3AR | |
| SCHEMBL16927217 | 0.75 | AR (0.54) | HTR1ASLC6A2SLC6A3MAPK1CA12 | |
| SCHEMBL1150327 | 0.74 | MAPK1 (0.53) | HTR1ASLC6A2SLC6A3MAPK1CA12 | |
| Hydrochloric Acid SCHEMBL9727859 | 0.73 | MAPK1 (0.52) | HTR1ASLC6A2SLC6A3MAPK1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62187458-A | — | — | None | — | — | JP | disclosed |
| US-4758567-A | 7-(4-amino-piperazinyl)- or 7-(4-chloro-piperazinyl)quinolinone and azaquinolinone derivatives and pharmaceutical compositions containing them | ROTTAPHARM S.P.A. (IT) | 1988-07-19 | — | — | US | disclosed |
| EP-0224121-A3 | 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them | ROTTAPHARM S.p.A. (IT) | 1987-11-11 | — | — | EP | disclosed |
| JP-S62187458-A | 7-(4-AMINO-PIPERAZINYL)- OR 7-(4-CHLORO-PIPERAZINYL)QUINOLINONE AND AZAQUINOLINONE DERIVATIVES, MANUFACTURE AND DRUG COMPOSITION | RORER ITALIANA SPA | 1987-08-15 | — | — | JP | disclosed |
| EP-0224121-A2 | 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them | ROTTAPHARM S.p.A. (IT) | 1987-06-03 | — | — | EP | disclosed |