Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19152972 | 0.78 | CYP2A6 (0.39) | SMN1; SMN2CYP2A6HTTRPS6KA5PDK1 | |
| SCHEMBL230331 | 0.68 | F12 (0.59) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18237780 | 0.67 | POLB (0.37) | KDM4ECYP2A6POLBALDH1A1 | |
| Hydrochlorthiazide SCHEMBL9107872 | 0.66 | F12 (0.42) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2628342 | 0.65 | ADORA3 (0.54) | MAPTKDM4ENPC1SMN1; SMN2NFKB1 | |
| SCHEMBL25137217 | 0.64 | PARP15 (0.44) | MAPTNPC1SMN1; SMN2HTTPRNP | |
| SCHEMBL16608505 | 0.64 | CYP2A6 (0.36) | KDM4ECYP2A6HTR3EHTR3BHTR3A | |
| SCHEMBL10657900 | 0.63 | PRNP (0.37) | MAPTNPC1RAB9ASMN1; SMN2CYP2A6 | |
| SCHEMBL15643529 | 0.63 | PSMB8 (0.52) | MAPTKDM4ESMN1; SMN2HTTPOLB | |
| SCHEMBL25322717 | 0.61 | TNKS2 (0.57) | MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4786633-A | HIGHER ACTIVITY | TANABE SEIYAKU CO., LTD. (JP) | 1988-11-22 | — | — | US | disclosed |
| EP-0248645-A2 | Cephalosporin compounds | Tanabe Seiyaku Co., Ltd. (JP) | 1987-12-09 | — | — | EP | disclosed |