Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 4/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658218 | 0.89 | DHFR (0.44) | P2RX4SMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL10658802 | 0.82 | PTGDR2 (0.45) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL10654477 | 0.80 | P2RX4 (0.48) | P2RX4CYP19A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10658309 | 0.78 | KDM4E (0.41) | SMN1; SMN2KMT2ADHFRKDM4EHPGD | |
| SCHEMBL10656830 | 0.76 | PLK1 (0.42) | SMN1; SMN2MEN1KMT2AMAPK1NPSR1 | |
| SCHEMBL10660950 | 0.75 | P2RX4 (0.59) | P2RX4CYP19A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10654559 | 0.74 | DRD1 (0.41) | SMN1; SMN2KMT2ADHFRHPGDHTT | |
| SCHEMBL10655566 | 0.73 | P2RX4 (0.56) | P2RX4CYP19A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14160818 | 0.73 | P2RX4 (1.00) | P2RX4CYP19A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29904927 | 0.73 | P2RX4 (1.00) | P2RX4CYP19A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |