Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656830 | 0.89 | PLK1 (0.42) | PTGDR2MEN1KMT2APDE4APDE4B | |
| SCHEMBL10658199 | 0.82 | P2RX4 (0.55) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL10657751 | 0.82 | CNR1 (0.46) | PTGDR2MEN1KMT2ACNR1CNR2 | |
| SCHEMBL9629995 | 0.81 | FEN1 (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10659571 | 0.78 | PTGDR2 (0.45) | PTGDR2MEN1KMT2ACNR1CNR2 | |
| SCHEMBL10657054 | 0.76 | ENPP2 (0.43) | PTGDR2MEN1KMT2ACNR1CNR2 | |
| SCHEMBL9630915 | 0.76 | HPGD (0.38) | MEN1KMT2APDE4APDE4BPDE4D | |
| SCHEMBL10378796 | 0.76 | HPGD (0.44) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL10658218 | 0.74 | DHFR (0.44) | MEN1KMT2AL3MBTL1THRB | |
| SCHEMBL9629150 | 0.74 | MAPT (0.46) | MEN1KMT2APDE4APDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |