Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 12/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656631 | 0.85 | ALDH1A1 (0.49) | ACELMNAACE2SMN1; SMN2 | |
| SCHEMBL10889619 | 0.82 | TSHR (0.56) | ACELMNAACE2RENKDM4E | |
| SCHEMBL10656762 | 0.82 | ACE (0.53) | ACELMNAACE2SMN1; SMN2REN | |
| SCHEMBL7412842 | 0.78 | ACE (0.48) | ACELMNAACE2SMN1; SMN2REN | |
| SCHEMBL30051731 | 0.78 | REN (0.47) | ACELMNAACE2RENKDM4E | |
| SCHEMBL7382443 | 0.78 | ACE (0.48) | ACELMNAACE2SMN1; SMN2REN | |
| SCHEMBL7372855 | 0.78 | ACE (0.48) | ACELMNAACE2SMN1; SMN2REN | |
| SCHEMBL7372850 | 0.78 | ACE (0.48) | ACELMNAACE2SMN1; SMN2REN | |
| SCHEMBL10719498 | 0.78 | KMT2A (0.49) | ACELMNAACE2RENKDM4E | |
| SCHEMBL10719504 | 0.78 | KMT2A (0.49) | ACELMNAACE2RENKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4719200-A | Amino acid derivatives and antihypertensive drugs containing the same | AJINOMOTO CO., INC. (JP) | 1988-01-12 | — | — | US | disclosed |
| EP-0173510-A2 | Tripeptide derivatives for use as anti-hypertensive agents | AJINOMOTO CO., INC. (JP) | 1986-03-05 | — | — | EP | disclosed |