Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 10/20 | 0.77 |
| ▸ | GSK3B | P49841 | 10/20 | 0.77 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.64 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | PRF1 | P14222 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065847 | 1.00 | GSK3A (0.77) | GSK3AGSK3BPIK3CGSIRT2HSPD1 | |
| SCHEMBL5145230 | 0.91 | SIRT2 (0.78) | GSK3AGSK3BPIK3CGSIRT2HSPD1 | |
| SCHEMBL13388774 | 0.89 | GSK3A (0.72) | GSK3AGSK3BPIK3CGSIRT2PRF1 | |
| SCHEMBL5143164 | 0.87 | GSK3A (1.00) | GSK3AGSK3BPIK3CGPRF1KMT2A | |
| SCHEMBL5143166 | 0.87 | GSK3A (1.00) | GSK3AGSK3BPIK3CGPRF1KMT2A | |
| SCHEMBL12990070 | 0.82 | PIK3CG (0.83) | GSK3AGSK3BPIK3CGSIRT2HSPD1 | |
| SCHEMBL3366739 | 0.82 | PIK3CG (0.83) | GSK3AGSK3BPIK3CGSIRT2HSPD1 | |
| SCHEMBL3366741 | 0.82 | PIK3CG (0.83) | GSK3AGSK3BPIK3CGSIRT2HSPD1 | |
| SCHEMBL5145152 | 0.82 | GSK3A (0.78) | GSK3AGSK3BSIRT2HSPD1HSPE1 | |
| SCHEMBL5145154 | 0.82 | GSK3A (0.78) | GSK3AGSK3BSIRT2HSPD1HSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735445-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-1594438-B1 | Use of an inhibitor of 15-hydroxyprostaglandin dehydrogenase in order to stimulate pigmentation of the skin or hair | OREAL (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2011-01-20 | — | — | US | disclosed |
| US-7705041-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2010-04-27 | — | — | US | disclosed |
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2008-03-27 | — | — | US | disclosed |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2006-02-16 | — | — | US | disclosed |
| US-20060008436-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | SOCIETE L'OREAL S.A. (FR) | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076809-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss composition comprising it and its uses | KRT18, FGF1, SHH | GSK3A 1635/4885GSK3B 1030/4885PIK3CG 3220/4885 |
| US-20060034786-A1 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | COX15, HPGD, TYR | GSK3A 3020/4885GSK3B 3374/4885PIK3CG 4500/4885 |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | COX15, HPGD, TYR | GSK3A 3020/4885GSK3B 3374/4885PIK3CG 4500/4885 |
| US-20060008436-A1 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses | KRT18, SHH, FGF1 | GSK3A 1332/4885GSK3B 903/4885PIK3CG 2886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.