Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | DGKI | O75912 | 1/20 | 0.33 |
| ▸ | DGKA | P23743 | 1/20 | 0.33 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659704 | 0.90 | PDE4A (0.36) | CREBBPPDE4ARENPDE4BPDE4D | |
| SCHEMBL10657023 | 0.89 | USP14 (0.42) | HPGDADORA3EP300CREBBPKAT2A | |
| SCHEMBL10379155 | 0.85 | HPGD (0.36) | HPGDPDE4BPDE4DLMNAKMT2A | |
| SCHEMBL9629754 | 0.83 | HPGD (0.47) | HPGDEP300CREBBPKAT2AKAT2B | |
| SCHEMBL10657158 | 0.82 | HKDC1 (0.39) | HPGDCREBBPHKDC1RAB9AKMT2A | |
| SCHEMBL10657718 | 0.82 | MEN1 (0.40) | HPGDCREBBPPDE4APDE4BPDE4D | |
| SCHEMBL10654513 | 0.81 | KAT2B (0.41) | HPGDCREBBPKAT2BPDE4BPDE4D | |
| SCHEMBL10657059 | 0.80 | PDE4B (0.39) | HPGDCREBBPPDE4APDE4BPDE4D | |
| SCHEMBL10658485 | 0.78 | HPGD (0.37) | HPGDADORA3EP300CREBBPKAT2A | |
| SCHEMBL10657805 | 0.77 | ALDH1A1 (0.40) | HPGDHKDC1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |