Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659132 | 0.88 | HIF1A (0.41) | PPARDGPBAR1FFAR1PTGS1PTPN1 | |
| Brocrinat SCHEMBL29452050 | 0.81 | PPARG (0.43) | PPARGPPARDPPARAFFAR1PTPN1 | |
| Brocrinat SCHEMBL636178 | 0.81 | PPARG (0.43) | PPARGPPARDPPARAFFAR1PTPN1 | |
| SCHEMBL10657153 | 0.79 | HIF1A (0.42) | PPARDGPBAR1FFAR1PTGS1ALOX5AP | |
| SCHEMBL10662754 | 0.76 | FHIT (0.47) | PPARGPPARDPPARAFFAR1NPC1 | |
| SCHEMBL10663597 | 0.73 | PPARG (0.45) | PPARGPPARDPPARAFFAR1ALOX5AP | |
| SCHEMBL10655898 | 0.73 | KMT2A (0.38) | PPARDGPBAR1GABRA5FFAR1PTGS1 | |
| SCHEMBL10660502 | 0.73 | PKM (0.45) | FFAR1PTPN1NPC1ALOX5APFEN1 | |
| SCHEMBL10662925 | 0.72 | PPARG (0.40) | PPARGPPARDPPARAGABRA5FFAR1 | |
| SCHEMBL10656083 | 0.72 | PPARG (0.43) | PPARGPPARDPPARAFFAR1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0002666-B1 | 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-17 | — | — | EP | disclosed |