Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810420 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1TDP1HRH3PRMT6 | |
| SCHEMBL7805242 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1TDP1HRH3PRMT6 | |
| SCHEMBL9574835 | 0.78 | HRH2 (0.55) | SMN1; SMN2ALDH1A1HRH3KDM4ECYP2D6 | |
| SCHEMBL11268821 | 0.77 | HRH2 (0.54) | SMN1; SMN2HRH3CYP2D6HIF1A | |
| SCHEMBL10401250 | 0.77 | HRH2 (0.54) | SMN1; SMN2HRH3CYP2D6HIF1A | |
| SCHEMBL7813997 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1TDP1HRH3PRMT6 | |
| SCHEMBL10668832 | 0.76 | PRMT6 (0.50) | SMN1; SMN2ALDH1A1TDP1HRH3PRMT6 | |
| SCHEMBL10744580 | 0.76 | HRH2 (0.53) | SMN1; SMN2ALDH1A1HRH3KDM4ECYP2D6 | |
| SCHEMBL10667188 | 0.76 | HRH2 (0.53) | HRH3 | |
| SCHEMBL11263724 | 0.76 | HRH2 (0.53) | SMN1; SMN2HRH3CYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4767769-A | HISTAMINE-H2 ANTAGONISTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| EP-0172631-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1986-02-26 | — | — | EP | disclosed |