Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 13/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10669667 | 0.80 | HIF1A (0.62) | HIF1ALMNAGALR3ADRB2ADRB1 | |
| SCHEMBL10665542 | 0.79 | TDP1 (0.37) | HIF1ALMNAADRB1MAPTKMT2A | |
| SCHEMBL10667097 | 0.78 | HIF1A (0.49) | HIF1ALMNAGALR3ADRB2ADRB1 | |
| SCHEMBL10668669 | 0.78 | ADRB2 (0.52) | ADRB2ADRB1DRD2DRD3ADRB3 | |
| SCHEMBL10664612 | 0.78 | ADRB3 (0.47) | HIF1ALMNAGALR3ADRB2ADRB1 | |
| SCHEMBL11372678 | 0.78 | ADRB2 (0.45) | ADRB2ADRB1DRD2DRD1DRD3 | |
| SCHEMBL11369828 | 0.77 | ADRB2 (0.43) | ADRB2ADRB1DRD2DRD1DRD3 | |
| SCHEMBL11365589 | 0.77 | ADRB2 (0.49) | ADRB2ADRB1DRD2DRD1DRD3 | |
| SCHEMBL10668774 | 0.77 | ADRB3 (0.65) | ADRB2ADRB3 | |
| SCHEMBL11369439 | 0.77 | ADRB2 (0.49) | ADRB2ADRB1DRD2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4721717-A | α-(aminoalkylaminomethyl)phenylmethanols, composition containing them, and use thereof to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-01-26 | — | — | US | disclosed |