Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 16/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 15/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 16/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664612 | 0.91 | ADRB3 (0.47) | ADRB2ADRB1HTR1AADRA2ADRD2 | |
| SCHEMBL10668774 | 0.83 | ADRB3 (0.65) | ADRB2ADRB3 | |
| SCHEMBL10667097 | 0.81 | HIF1A (0.49) | ADRB2ADRB1HTR1AADRA2AADRA2B | |
| SCHEMBL10669667 | 0.80 | HIF1A (0.62) | ADRB2ADRB1HTR1AADRA2AADRA2B | |
| SCHEMBL10665538 | 0.78 | HIF1A (0.42) | ADRB2ADRB1ADRA2ADRD2ADRA2B | |
| SCHEMBL11880976 | 0.75 | ADRB2 (0.60) | ADRB2ADRB1HTR1ADRD2ADRA2B | |
| SCHEMBL11873820 | 0.74 | ADRB2 (0.65) | ADRB2ADRB1HTR1ADRD2ADRA2B | |
| SCHEMBL11473130 | 0.73 | ADRB2 (0.83) | ADRB2ADRB1HTR1AADRA2ADRD2 | |
| SCHEMBL11477204 | 0.73 | ADRB2 (0.70) | ADRB2ADRB1HTR1AADRA2ADRD2 | |
| SCHEMBL11874139 | 0.73 | ADRB2 (0.66) | ADRB2ADRB1DRD2ADRA1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4721717-A | α-(aminoalkylaminomethyl)phenylmethanols, composition containing them, and use thereof to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-01-26 | — | — | US | disclosed |
| EP-0171689-A1 | Aminoalcohols, process for their preparation and medicaments containing these compounds and intermediates | Roche Diagnostics GmbH (DE) | 1986-02-19 | — | — | EP | disclosed |