Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoromethylbenzene SCHEMBL10351140 | 0.79 | LMNA (0.57) | NPC1RAB9ALMNATSHRFFAR2 | |
| SCHEMBL1340202 | 0.76 | P2RY1 (0.56) | P2RY1 | |
| SCHEMBL3151530 | 0.76 | P2RY1 (0.71) | NPSR1P2RY1 | |
| SCHEMBL12241949 | 0.76 | SCN9A (0.50) | LMNATSHRFFAR2NPSR1TP53 | |
| SCHEMBL12617322 | 0.73 | ATM (0.52) | NPSR1ATM | |
| SCHEMBL10351141 | 0.71 | PKM (0.54) | NPC1RAB9ALMNAAURKATSHR | |
| SCHEMBL9839295 | 0.71 | HTT (0.48) | NPC1RAB9ALMNATSHRFFAR2 | |
| SCHEMBL18838551 | 0.70 | ATM (0.50) | NPSR1ATM | |
| SCHEMBL10665884 | 0.70 | SMN1; SMN2 (0.46) | NPC1RAB9AHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2656886 | 0.70 | NPC1 (0.52) | NPC1RAB9ALMNAAURKANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0141713-B1 | Process for preparation of 2-substituted quinoline-3- carboxamides | ROUSSEL-UCLAF (FR) | 1990-05-30 | — | — | EP | disclosed |