Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9596923 | 0.90 | ATM (0.47) | HDAC1HDAC6KDM4EPTGS1PTGS2 | |
| SCHEMBL10658421 | 0.84 | KDM4E (0.43) | HDAC1HDAC6KDM4EPTGS1PTGS2 | |
| SCHEMBL9596229 | 0.81 | ALDH1A1 (0.50) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10664163 | 0.81 | KDM4E (0.41) | HDAC1HDAC6KDM4EPTGS1PTGS2 | |
| SCHEMBL10664295 | 0.80 | SCARB1 (0.42) | KDM4EPTGS1PTGS2MAPTALOX5 | |
| SCHEMBL1146660 | 0.80 | HTR2A (0.51) | HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL30223533 | 0.80 | HTR2A (0.51) | HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL10667198 | 0.79 | KDM4E (0.48) | HDAC1HDAC6KDM4EPTGS1PTGS2 | |
| SCHEMBL7292545 | 0.78 | PARP1 (0.45) | ATM | |
| SCHEMBL13877233 | 0.76 | ALOX5 (0.65) | PTGS1PTGS2ALOX5MEN1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725615-A | SELECTIVE FOR \"NEURONAL\" 5-HYDROXYTRYPTAMINE RECEPTORS; NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED | 1988-02-16 | — | — | US | disclosed |
| EP-0219193-A1 | Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1987-04-22 | — | — | EP | disclosed |