Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10666131 | 0.81 | HDAC1 (0.50) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL10658421 | 0.80 | KDM4E (0.43) | ALDH1A1KDM4EPKMMAPK1MAPT | |
| SCHEMBL31506882 | 0.79 | KDM4E (0.41) | ALDH1A1KDM4EPKMMAPK1MAPT | |
| SCHEMBL6919959 | 0.78 | HTR6 (0.59) | MAPK1KMT2A | |
| SCHEMBL10664163 | 0.78 | KDM4E (0.41) | ALDH1A1KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL10664295 | 0.77 | SCARB1 (0.42) | KDM4EMAPT | |
| SCHEMBL9616130 | 0.77 | ALOX5 (0.61) | ALDH1A1KDM4EMTNR1AMAPTHTT | |
| SCHEMBL1146660 | 0.76 | HTR2A (0.51) | ALDH1A1KDM4EMAPK1HSD17B10 | |
| SCHEMBL30223533 | 0.76 | HTR2A (0.51) | ALDH1A1KDM4EMAPK1HSD17B10 | |
| SCHEMBL9871263 | 0.76 | KDM4E (0.48) | ALDH1A1KDM4EPKMMTNR1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202343-A | Treating anxiety, psychological disorders | GLAXO GROUP LIMITED (GB) | 1993-04-13 | — | — | US | disclosed |
| EP-0219193-B1 | TETRAHYDROCARBAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1992-05-27 | — | — | EP | disclosed |
| US-4859662-A | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances | GLAXO GROUP LIMITED (GB) | 1989-08-22 | — | — | US | disclosed |
| US-4822881-A | PSYCHOTIC DISORDERS, ANXIETY, NAUSEA, VOMITING | GLAXO GROUP LIMITED | 1989-04-18 | — | — | US | disclosed |
| US-4725615-A | SELECTIVE FOR \"NEURONAL\" 5-HYDROXYTRYPTAMINE RECEPTORS; NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED | 1988-02-16 | — | — | US | disclosed |
| EP-0219193-A1 | Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1987-04-22 | — | — | EP | disclosed |