SCHEMBL10667342

SCHEMBL10667342

COC(=O)CCNCC(=O)OC

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.57
CA12 O43570 4/20 0.52
CA14 Q9ULX7 4/20 0.52
RECQL P46063 1/20 0.46
KMT2A Q03164 3/20 0.43
TET2 Q6N021 1/20 0.43
MEN1 O00255 1/20 0.43
LMNA P02545 3/20 0.42
ALDH1A1 P00352 3/20 0.42
KDM4E B2RXH2 1/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
HSD17B10 Q99714 2/20 0.40
MAPT P10636 2/20 0.40
CA2 P00918 1/20 0.40
MGAM O43451 1/20 0.40
GAA P10253 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL15654082 0.98 TSHR (0.55) TSHRCA12CA14RECQLKMT2A
SCHEMBL2361759 0.87 TSHR (0.50) TSHRCA12CA14RECQLKMT2A
SCHEMBL72889 0.87 TSHR (0.67) TSHRCA12CA14RECQLKMT2A
SCHEMBL17817739 0.86 TSHR (0.52) TSHRCA12CA14RECQLKMT2A
SCHEMBL7433528 0.86 TSHR (0.58) TSHRCA12CA14RECQLKMT2A
SCHEMBL13969418 0.86 TSHR (0.52) TSHRCA12CA14RECQLKMT2A
SCHEMBL10056635 0.85
SCHEMBL4335291 0.85 ALDH1A1 (0.50) TSHRCA12CA14RECQLKMT2A
SCHEMBL12847508 0.84 TSHR (0.63) TSHRCA12CA14RECQLKMT2A
SCHEMBL10042464 0.84 TSHR (0.63) TSHRCA12CA14RECQLKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114380717-A Process for the preparation of 3- (tert-butoxycarbonyl-methoxycarbonylmethyl-amino) -propionic acid methyl ester and intermediates thereof 郑州猫眼农业科技有限公司 2022-04-22 CN disclosed
EP-3303366-B1 DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF NEWBIO THERAPEUTICS INC (CN) 2020-09-30 EP disclosed
EP-2725016-B1 HETEROCYCLIC CARBOXYLIC ACID ESTER DERIVATIVE EA PHARMA CO LTD (JP) 2016-12-21 EP disclosed
WO-2016192527-A1 DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF NEWBIO THERAPEUTICS, INC. (CN) 2016-12-08 WO disclosed
US-9346821-B2 Heterocyclic carboxylic acid ester derivative AJINOMOTO CO., INC. (JP) 2016-05-24 US disclosed
EP-2725016-A1 HETEROCYCLIC CARBOXYLIC ACID ESTER DERIVATIVE Ajinomoto Co., Inc. (JP) 2014-04-30 EP disclosed
US-4789674-A ALZHEIMER'S DISEASE, MEMORY, DEMENTIA CIBA-GEIGY CORPORATION (US) 1988-12-06 US disclosed
US-4758575-A Bi-2H-pyrroli(di)nediones CIBA-GEIGY CORPORATION (US) 1988-07-19 US disclosed