Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109000 | 0.92 | CYP19A1 (0.54) | MMP12MMP13CYP19A1KCNH2LSS | |
| SCHEMBL4084185 | 0.82 | LOXL2 (0.48) | MMP12MMP13CYP19A1KCNJ1KCNH2 | |
| SCHEMBL13891122 | 0.81 | CA12 (0.41) | MMP12MMP13CYP19A1LOXL2CYP2A6 | |
| SCHEMBL3656126 | 0.79 | MMP12 (0.54) | MMP12MMP13CYP19A1KCNJ1KCNH2 | |
| SCHEMBL11980400 | 0.79 | CA12 (0.43) | MMP12MMP13CYP19A1LOXL2CYP2A6 | |
| SCHEMBL9647636 | 0.78 | TSHR (0.45) | CYP19A1CYP2A6TSHRHSD17B10 | |
| SCHEMBL2964767 | 0.76 | ADRB2 (0.62) | TSHRADRB2 | |
| SCHEMBL13174142 | 0.76 | CA12 (0.44) | CYP19A1LOXL2CYP2A6TSHR | |
| SCHEMBL11980418 | 0.76 | CA12 (0.44) | CYP19A1LOXL2CYP2A6TSHR | |
| SCHEMBL28239877 | 0.76 | CA12 (0.44) | CYP19A1LOXL2CYP2A6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4732907-A | Antiprotozoal diamidines and bis-imidazoline | PFIZER INC. (US) | 1988-03-22 | — | — | US | disclosed |
| US-4624958-A | Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles | PFIZER INC. (US) | 1986-11-25 | — | — | US | disclosed |
| US-4546113-A | Antiprotozoal diamidines | PFIZER INC. (US) | 1985-10-08 | — | — | US | disclosed |