SCHEMBL10668697

SCHEMBL10668697

Cc1csc2nc3cccc(F)c3c(=O)n12

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
HPGD P15428 4/20 0.62
HSD17B10 Q99714 4/20 0.62
KDM4E B2RXH2 3/20 0.62
GLA P06280 1/20 0.47
SMN1; SMN2 Q16637 4/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
RCE1 Q9Y256 1/20 0.45
PARP1 P09874 1/20 0.44
PKM P14618 2/20 0.41
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
PIK3CD O00329 1/20 0.39
POLB P06746 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL11085283 0.99 ALDH1A1 (0.60) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL9532203 0.86 KDM4E (0.65) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL9535003 0.83 ALDH1A1 (0.62) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL9533630 0.83 KDM4E (0.62) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL9770613 0.83 KDM4E (0.61) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL9532680 0.81 KDM4E (0.63) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL9534712 0.81 KDM4E (0.59) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL9538352 0.78 KDM4E (0.55) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL10696506 0.78 ALDH1A1 (0.62) ALDH1A1HPGDHSD17B10KDM4EGLA
SCHEMBL10695051 0.78 TP53 (0.46) ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4486221-A POSTEMERGENCE HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1984-12-04 US claimed
US-4726837-A Use of 4H-pyrido[2,3-d][1,3]oxazin-4-one derivatives for controlling undesirable plant growth BASF AKTIENGESELLSCHAFT (DE) 1988-02-23 US disclosed
US-4692187-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1987-09-08 US disclosed
EP-0078003-B1 THIAZOLO (2,3-B)-QUINAZOLONES AND PROCESS FOR THEIR PREPARATION BASF Aktiengesellschaft (DE) 1986-03-05 EP disclosed
EP-0078003-A2 Thiazolo (2,3-b)-quinazolones and process for their preparation BASF Aktiengesellschaft (DE) 1983-05-04 EP disclosed