Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777049 | 0.82 | LMNA (0.72) | NR1H3NR1H2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4854039 | 0.79 | NR1H3 (0.62) | NR1H3NR1H2LMNAALDH1A1HTT | |
| SCHEMBL10672038 | 0.77 | KDM4E (0.54) | LMNAALDH1A1SMN1; SMN2HSP90AA1HTT | |
| SCHEMBL11743353 | 0.77 | ALDH1A1 (0.69) | NR1H3NR1H2LMNAALDH1A1HSP90AA1 | |
| SCHEMBL9053567 | 0.75 | ALDH1A1 (0.67) | NR1H3NR1H2LMNAALDH1A1HSP90AA1 | |
| SCHEMBL8828667 | 0.72 | ABCB1 (0.69) | NR1H3NR1H2LMNAALDH1A1 | |
| SCHEMBL10666590 | 0.72 | HRH1 (0.49) | LMNAADRA1AMAPK1MAPT | |
| SCHEMBL10926180 | 0.72 | CASP3 (0.56) | HTTADRA1DADRA1AADRA1BMAPK1 | |
| SCHEMBL2593843 | 0.71 | ALDH1A1 (0.64) | NR1H3NR1H2LMNAALDH1A1HSP90AA1 | |
| SCHEMBL10672263 | 0.71 | MAPT (0.55) | LMNAALDH1A1HSP90AA1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785010-A | AGING RESISTANCE OF HUMANS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1988-11-15 | — | — | US | disclosed |
| EP-0124067-B1 | 2-(AMINOALKYL)-PYRROLE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1986-12-17 | — | — | EP | disclosed |
| EP-0124067-A1 | 2-(Aminoalkyl)-pyrrole derivatives, process for their manufacture and their use | CASSELLA Aktiengesellschaft (DE) | 1984-11-07 | — | — | EP | disclosed |