Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 3/20 | 0.52 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.46 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.46 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.46 |
| ▸ | TK2 | O00142 | 2/20 | 0.46 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CDA | P32320 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18512917 | 0.88 | PYGM (0.63) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL40820 | 0.88 | PYGM (0.63) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL40819 | 0.88 | PYGM (0.63) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL18503568 | 0.88 | PYGM (0.63) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL18512919 | 0.88 | PYGM (0.63) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL27760732 | 0.88 | PYGM (0.51) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL441977 | 0.85 | PYGM (0.48) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL21683245 | 0.85 | PYGM (0.48) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL20534354 | 0.85 | PYGM (0.48) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL3841360 | 0.85 | PYGM (0.48) | PYGMSLC28A1SLC28A2SLC29A1SLC28A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110014214-A1 | Diagnostic and Therapeutic Utility of Tribbles-2 in Human Cancers | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2011-01-20 | — | — | US | disclosed |
| US-7501281-B2 | Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells | MAINE MEDICAL CENTER RESEARCH INSTITUTE (US) | 2009-03-10 | — | — | US | disclosed |
| US-7304138-B2 | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids | MAINE MEDICAL CENTER RESEARCH INSTITUTE (US) | 2007-12-04 | — | — | US | disclosed |
| WO-2007084757-A2 | DIAGNOSTIC AND THERAPEUTIC UTILITY OF TRIBBLES-2 IN HUMAN CANCERS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2006125001-A2 | COMPOSITIONS AND METHODS RELATED TO THE INTRACELLULAR EFFECTS OF INTRACELLULAR DOMAINS OF DELTA1 AND JAGGED1 | MAINE MEDICAL CENTER RESEARCH INSTITUTE (US) | 2006-11-23 | — | — | WO | disclosed |
| US-20060084599-A1 | Compositions, methods and kits relating to notch signaling | MAINE MEDICAL CENTER | 2006-04-20 | — | — | US | disclosed |
| US-20060063253-A1 | Compositions, methods and kits relating to thrombin, Notch signaling and stamatogenesis and growth of stem cells | MAINE MEDICAL CENTER RESEARCH INSTITUTE | 2006-03-23 | — | — | US | disclosed |
| US-20040253602-A1 | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids | MAINE MEDICAL CENTER RESEARCH INSTITUTE | 2004-12-16 | — | — | US | disclosed |
| WO-2004078944-A2 | THROMBIN, SOLUBLE JAGGEDI, AND TRAP AND GROWTH OF STEM CELLS | MAINE MEDICAL CENTER RESEARCH INSTITUTE (US) | 2004-09-16 | — | — | WO | disclosed |
| US-6716974-B1 | THE ADDITION OR INCREASED EXPRESSION OF JAGGED DECREASES THE MIGRATION AND INVASION OF MICROVASCULAR CELLS FROM THE VASO VASORUM, AND INCREASES OR STIMULATES THE MIGRATION OF LARGE VESSEL ENDOTHELIAL CELLS. | MAINE MEDICAL CENTER RESEARCH INSTITUTE | 2004-04-06 | — | — | US | disclosed |